Genomics and Biochemistry of Metabolic Pathways for the C₁ Compounds Utilization in Colorless Sulfur Bacterium Beggiatoa leptomitoformis D-402.

ABSTRACT: The metabolic pathways of one-carbon compounds utilized by colorless sulfur bacterium Beggiatoa leptomitoformis D-402 were revealed based on comprehensive analysis of its genomic organization, together with physiological, biochemical and molecular biological approaches. Strain D-402 was capable of aerobic methylotrophic growth with methanol as a sole source of carbon and energy and was not capable of methanotrophic growth because of the absence of genes of methane monooxygenases. It was established that methanol can be oxidized to CO₂ in three consecutive stages. On the first stage methanol was oxidized to formaldehyde by the two PQQ (pyrroloquinolinequinone)-dependent methanol dehydrogenases (MDH): XoxF and Mdh2. Formaldehyde was further oxidized to formate via the tetra

SUBMITTER: Orlova MV 

PROVIDER: S-EPMC6141403 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature