Kidney-resident macrophages promote a proangiogenic environment in the normal and chronically ischemic mouse kidney.

ABSTRACT: Renal artery stenosis (RAS) caused by narrowing of arteries is characterized by microvascular damage. Macrophages are implicated in repair and injury, but the specific populations responsible for these divergent roles have not been identified. Here, we characterized murine kidney F4/80⁺CD64⁺ macrophages in three transcriptionally unique populations. Using fate-mapping and parabiosis studies, we demonstrate that CD11b/c^int are long-lived kidney-resident (KRM) while CD11c^hiMϕ, CD11c^loMϕ are monocyte-derived macrophages. In a murine model of RAS, KRM self-renewed, while CD11c^hiMϕ and CD11c^loMϕ increased significantly, which was associated with loss of peritubular capillaries. Replacing the native KRM with monocyte-de

SUBMITTER: Puranik AS 

PROVIDER: S-EPMC6141464 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature