Spatio-temporal characteristics of population responses evoked by microstimulation in the barrel cortex.

ABSTRACT: Intra-cortical microstimulation (ICMS) is a widely used technique to artificially stimulate cortical tissue. This method revealed functional maps and provided causal links between neuronal activity and cognitive, sensory or motor functions. The effects of ICMS on neural activity depend on stimulation parameters. Past studies investigated the effects of stimulation frequency mainly at the behavioral or motor level. Therefore the direct effect of frequency stimulation on the evoked spatio-temporal patterns of cortical activity is largely unknown. To study this question we used voltage-sensitive dye imaging to measure the population response in the barrel cortex of anesthetized rats evoked by high frequency stimulation (HFS), a lower frequency stimulation (LFS) of the same duration or a singl

SUBMITTER: Margalit SN 

PROVIDER: S-EPMC6141467 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature