Differential regulation of chloride homeostasis and GABAergic transmission in the thalamus.

ABSTRACT: The thalamus is important for sensory integration with the ventrobasal thalamus (VB) as relay controlled by GABAergic projections from the nucleus reticularis thalami (NRT). Depending on the [Cl^-]_i primarily set by cation-chloride-cotransporters, GABA is inhibitory or excitatory. There is evidence that VB and NRT differ in terms of GABA action, with classical hyperpolarization in VB due to the expression of the Cl^- extruder KCC2 and depolarizing/excitatory GABA action in the NRT, where KCC2 expression is low and Cl^- accumulation by the Cl^- inward transporter NKCC1 has been postulated. However, data on NKCC1 expression and functional analysis of both transporters are missing. We show that KCC2-mediated Cl^- extrusion set the [

SUBMITTER: Schmidt T 

PROVIDER: S-EPMC6141474 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature