Proteomic analysis reveals distinctive protein profiles involved in CD8⁺ T cell-mediated murine autoimmune cholangitis.

ABSTRACT: Autoimmune cholangitis arises from abnormal innate and adaptive immune responses in the liver, and T cells are critical drivers in this process. However, little is known about the regulation of their functional behavior during disease development. We previously reported that mice with T cell-restricted expression of a dominant negative form of transforming growth factor beta receptor type II (dnTGFβRII) spontaneously develop an autoimmune cholangitis that resembles human primary biliary cholangitis (PBC). Adoptive transfer of CD8⁺ but not CD4⁺ T cells into Rag1^-/- mice reproduced the disease, demonstrating a critical role for CD8⁺ T cells in PBC pathogenesis. Herein, we used SOMAscan technology to perform proteomic analysis of serum samples from

SUBMITTER: Zhang W 

PROVIDER: S-EPMC6141482 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature