Epitopes identified in GAPDH from Clostridium difficile recognized as common antigens with potential autoimmunizing properties.

ABSTRACT: Clostridium difficile (CD) infections are a growing threat due to the strain resistance to antibiotic treatment and the emergence of hypervirulent strains. One solution to this problem is the search for new vaccine antigens, preferably surface-localized that will be recognized by antibodies at an early stage of colonization. The purpose of the study was to assess the usefulness of novel immunoreactive surface proteins (epitopes) as potential vaccine antigens. Such approach might be tough to pursue since pathogens have acquired strategies to subvert adaptive immune response to produce humoral response against non-essential proteins for their survival. In this study CD surface proteins were isolated, immunoreactive proteins identified and mapped to select potential epitopes. The results of t

SUBMITTER: Razim A 

PROVIDER: S-EPMC6141484 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature