Neural stem cells deriving from chick embryonic hindbrain recapitulate hindbrain development in culture.

ABSTRACT: Neural stem cells (NSCs) are self-renewing multipotent cells that line the neural-tube and generate all the nervous system. Understanding NSC biology is fundamental for neurodevelopmental research and therapy. Many studies emphasized the need to culture NSCs, which are typically purified from mammalian embryonic/adult brains. These sources are somewhat limited in terms of quantity, availability and animal ethical guidelines. Therefore, new sources are needed. The chick is a powerful system for experimental embryology which contributed enormously to neurodevelopmental concepts. Its accessibility, genetic/molecular manipulations, and homology to other vertebrates, makes it valuable for developmental biology research. Recently, we identified a population of NSCs in the chick hindbrain. It res

SUBMITTER: Peretz Y 

PROVIDER: S-EPMC6141497 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature