Engineered Human Contractile Myofiber Sheets as a Platform for Studies of Skeletal Muscle Physiology.

ABSTRACT: Skeletal muscle physiology and the mechanisms of muscle diseases can be effectively studied by an in-vitro tissue model produced by muscle tissue engineering. Engineered human cell-based tissues are required more than ever because of the advantages they bring as tissue models in research studies. This study reports on a production method of a human skeletal myofiber sheet that demonstrates biomimetic properties including the aligned structure of myofibers, basement membrane-like structure of the extracellular matrix, and unidirectional contractile ability. The contractile ability and drug responsibility shown in this study indicate that this engineered muscle tissue has potential as a human cell-based tissue model for clinically relevant in-vitro studies in muscle physiology and drug disco

SUBMITTER: Takahashi H 

PROVIDER: S-EPMC6141563 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature