NagR_Bt Is a Pleiotropic and Dual Transcriptional Regulator in Bacillus thuringiensis.

ABSTRACT: NagR, belonging to the GntR/HutC family, is a negative regulator that directly represses the nagP and nagAB genes, which are involved in GlcNAc transport and utilization in Bacillus subtilis. Our previous work confirmed that the chitinase B gene (chiB) of Bacillus thuringiensis strain Bti75 is also negatively controlled by YvoA_Bt, the ortholog of NagR from B. subtilis. In this work, we investigated its regulatory network in Bti75 and found that YvoA_Bt is an N-acetylglucosamine utilization regulator primarily involved in GlcNAc catabolism; therefore YvoA_Bt is renamed as NagR_Bt. The RNA-seq data revealed that 27 genes were upregulated and 14 genes were downregulated in the ΔnagR mutant compared with

SUBMITTER: Cao ZL 

PROVIDER: S-EPMC6141813 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature