Microglia inhibit photoreceptor cell death and regulate immune cell infiltration in response to retinal detachment.

ABSTRACT: Retinal detachment (RD) is a sight-threatening complication common in many highly prevalent retinal disorders. RD rapidly leads to photoreceptor cell death beginning within 12 h following detachment. In patients with sustained RD, progressive visual decline due to photoreceptor cell death is common, leading to significant and permanent loss of vision. Microglia are the resident immune cells of the central nervous system, including the retina, and function in the homeostatic maintenance of the neuro-retinal microenvironment. It is known that microglia become activated and change their morphology in retinal diseases. However, the function of activated microglia in RD is incompletely understood, in part because of the lack of microglia-specific markers. Here, using the newly identified microg

SUBMITTER: Okunuki Y 

PROVIDER: S-EPMC6142210 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature