Myocardial insufficiency is related to reduced subunit 4 content of cytochrome c oxidase.

ABSTRACT:

Background

Treatment of heart failure remains one of the most challenging task for intensive care medicine, cardiology and cardiac surgery. New options and better indicators are always required. Understanding the basic mechanisms underlying heart failure promote the development of adjusted therapy e.g. assist devices and monitoring of recovery. If cardiac failure is related to compromised cellular respiration of the heart, remains unclear. Myocardial respiration depends on Cytochrome c- Oxidase (CytOx) activity representing the rate limiting step for the mitochondrial respiratory chain. The enzymatic activity as well as mRNA expression of enzyme's mitochondrial encoded catalytic subunit 2, nuclear encoded regulatory subunit 4 and protein contents were studied in biopsies of cardiac

SUBMITTER: Vogt S 

PROVIDER: S-EPMC6142347 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature