Aptamer-based search for correlates of plasma and serum water T₂: implications for early metabolic dysregulation and metabolic syndrome.

ABSTRACT:

Background

Metabolic syndrome is a cluster of abnormalities that increases the risk for type 2 diabetes and atherosclerosis. Plasma and serum water T₂ from benchtop nuclear magnetic resonance relaxometry are early, global and practical biomarkers for metabolic syndrome and its underlying abnormalities. In a prior study, water T₂ was analyzed against ~ 130 strategically selected proteins and metabolites to identify associations with insulin resistance, inflammation and dyslipidemia. In the current study, the analysis was broadened ten-fold using a modified aptamer (SOMAmer) library, enabling an unbiased search for new proteins correlated with water T₂ and thus, metabolic health.

Methods

Water T₂ measurements were recorded using fast

SUBMITTER: Patel V 

PROVIDER: S-EPMC6142358 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature