Systematic identification of the key candidate genes in breast cancer stroma.

ABSTRACT:

Background

Tumor microenvironment, in particular the stroma, plays an important role in breast cancer cell invasion and metastasis. Investigation of the molecular characteristics of breast cancer stroma may reveal targets for future study.

Methods

The transcriptome profiles of breast cancer stroma and normal breast stroma were compared to identify differentially expressed genes (DEGs). The method was analysis of GSE26910 and GSE10797 datasets. Common DEGs were identified and then analyses of enriched pathways and hub genes were performed.

Results

A total of 146 DEGs were common to GSE26910 and GSE10797. The enriched pathways were associated with "extracellular matrix (ECM) organization", "ECM-receptor interaction" and "focal adhesion". Network analysis identified six

SUBMITTER: Wang Y 

PROVIDER: S-EPMC6142385 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature