Therapy of primary CNS lymphoma: role of intensity, radiation, and novel agents.

ABSTRACT: Primary central nervous system (CNS) lymphomas represent a subgroup of malignancies with specific characteristics, an aggressive course, and unsatisfactory outcome in contrast with other lymphomas comparable for tumor burden and histological type. Despite the high sensitivity to conventional chemotherapy and radiotherapy, remissions are frequently short lasting. Treatment efficacy is limited by several factors, including the biology and microenvironment of this malignancy and the "protective" effect of the blood-brain barrier, which limits the access of most drugs to the CNS. Patients who survive are at high risk of developing treatment-related toxicity, mainly disabling neurotoxicity, raising the question of how to balance therapy intensification with the control of side effects. Recent t

SUBMITTER: Ferreri AJM 

PROVIDER: S-EPMC6142584 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature