Emerging options in multiple myeloma: targeted, immune, and epigenetic therapies.

ABSTRACT: Considerable progress has been made in the treatment of multiple myeloma in the past decade with median survival for the disease improving significantly. This has come through a combination of better understanding of the disease biology and coordinated research into new treatment approaches including better supportive care. However, patients eventually become refractory to available treatments and succumb to the disease, highlighting the need to develop new treatment approaches. The genetic heterogeneity in the disease and clonal evolution under treatment pressure underlie the development of resistance, underscoring the need to develop more effective therapies that can eradicate the disease at initial treatment as well as the need for new classes of drugs with varying mechanisms of action.

SUBMITTER: Kumar S 

PROVIDER: S-EPMC6142613 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature