Common DNA Variants Accurately Rank an Individual of Extreme Height.

ABSTRACT: Polygenic scores (or genetic risk scores) quantify the aggregate of small effects from many common genetic loci that have been associated with a trait through genome-wide association. Polygenic scores were first used successfully in schizophrenia and have since been applied to multiple phenotypes including multiple sclerosis, rheumatoid arthritis, and height. Because human height is an easily-measured and complex polygenic trait, polygenic height scores provide exciting insights into the predictability of aggregate common variant effect on the phenotype. Shawn Bradley is an extremely tall former professional basketball player from Brigham Young University and the National Basketball Association (NBA), measuring 2.29 meters (7'6^″, 99.99999th percentile for height) tall, with no k

SUBMITTER: Sexton CE 

PROVIDER: S-EPMC6142724 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature