A novel and practical asymmetric synthesis of eptazocine hydrobromide.

ABSTRACT: In order to prepare eptazocine hydrobromide effectively, a novel, mild and practical asymmetric process was developed starting from 1-methyl-7-methoxy-2-tetralone under the catalysis of N-(p-trifluoromethylbenzyl)cinchonidinium bromide. The reaction conditions were optimized to obtain the product in excellent overall yield and purity.

SUBMITTER: Li R 

PROVIDER: S-EPMC6142761 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature