Distinct Graft-Specific TCR Avidity Profiles during Acute Rejection and Tolerance.

ABSTRACT: Mechanisms implicated in robust transplantation tolerance at the cellular level can be broadly categorized into those that inhibit alloreactive T cells intrinsically (clonal deletion and dysfunction) or extrinsically through regulation. Here, we investigated whether additional population-level mechanisms control T cells by examining whether therapeutically induced peripheral transplantation tolerance could influence T cell populations' avidity for alloantigens. Whereas T cells with high avidity preferentially accumulated during acute rejection of allografts, the alloreactive T cells in tolerant recipients retained a low-avidity profile, comparable to naive mice despite evidence of activation. These contrasting avidity profiles upon productive versus tolerogenic stimulation were durable and

SUBMITTER: Miller ML 

PROVIDER: S-EPMC6142813 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature