Mutational landscape of a chemically-induced mouse model of liver cancer.

ABSTRACT:

Background & aims

Carcinogen-induced mouse models of liver cancer are used extensively to study the pathogenesis of the disease and are critical for validating candidate therapeutics. These models can recapitulate molecular and histological features of human disease. However, it is not known if the genomic alterations driving these mouse tumour genomes are comparable to those found in human tumours. Herein, we provide a detailed genomic characterisation of tumours from a commonly used mouse model of hepatocellular carcinoma (HCC).

Methods

We analysed whole exome sequences of liver tumours arising in mice exposed to diethylnitrosamine (DEN). Mutational signatures were compared between liver tumours from DEN-treated and untreated mice, and human HCCs.

Results

DEN-initia

SUBMITTER: Connor F 

PROVIDER: S-EPMC6142872 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature