Effect of Repetitive Transcranial Magnetic Stimulation on Treatment-Resistant Major Depression in US Veterans: A Randomized Clinical Trial.

ABSTRACT:

Importance

Treatment-resistant major depression (TRMD) in veterans is a major clinical challenge given the high risk for suicidality in these patients. Repetitive transcranial magnetic stimulation (rTMS) offers the potential for a novel treatment modality for these veterans.

Objective

To determine the efficacy of rTMS in the treatment of TRMD in veterans.

Design, setting, and participants

A double-blind, sham-controlled randomized clinical trial was conducted from September 1, 2012, to December 31, 2016, in 9 Veterans Affairs medical centers. A total of 164 veterans with TRD participated.

Interventions

Participants were randomized to either left prefrontal rTMS treatment (10 Hz, 120% motor threshold, 4000 pulses/session) or to sham (control) rTMS treatment for

SUBMITTER: Yesavage JA 

PROVIDER: S-EPMC6142912 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature