DNA Methylation Signatures of Depressive Symptoms in Middle-aged and Elderly Persons: Meta-analysis of Multiethnic Epigenome-wide Studies.

ABSTRACT:

Importance

Depressive disorders arise from a combination of genetic and environmental risk factors. Epigenetic disruption provides a plausible mechanism through which gene-environment interactions lead to depression. Large-scale, epigenome-wide studies on depression are missing, hampering the identification of potentially modifiable biomarkers.

Objective

To identify epigenetic mechanisms underlying depression in middle-aged and elderly persons, using DNA methylation in blood.

Design, setting, and participants

To date, the first cross-ethnic meta-analysis of epigenome-wide association studies (EWAS) within the framework of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium was conducted. The discovery EWAS included 7948 individuals of

SUBMITTER: Story Jovanova O 

PROVIDER: S-EPMC6142917 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature