Comparison of Safety and Efficacy of Methadone vs Morphine for Treatment of Neonatal Abstinence Syndrome: A Randomized Clinical Trial.

ABSTRACT:

Importance

Although opioids are used to treat neonatal abstinence syndrome (NAS), the best pharmacologic treatment has not been established.

Objective

To compare the safety and efficacy of methadone and morphine in NAS.

Design, setting, and participants

In this randomized, double-blind, intention-to-treat trial, term infants from 8 US newborn units whose mothers received buprenorphine, methadone, or opioids for pain control during pregnancy were eligible. A total of 117 infants were randomized to receive methadone or morphine from February 9, 2014, to March 6, 2017. Mothers who declined randomization could consent to data collection and standard institutional treatment.

Interventions

Infants were assessed with the Finnegan Neonatal Abstinence Scoring System eve

SUBMITTER: Davis JM 

PROVIDER: S-EPMC6142918 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature