Sex-Specific Association of Apolipoprotein E With Cerebrospinal Fluid Levels of Tau.

ABSTRACT:

Importance

The strongest genetic risk factor for Alzheimer disease (AD), the apolipoprotein E (APOE) gene, has a stronger association among women compared with men. Yet limited work has evaluated the association between APOE alleles and markers of AD neuropathology in a sex-specific manner.

Objective

To evaluate sex differences in the association between APOE and markers of AD neuropathology measured in cerebrospinal fluid (CSF) during life or in brain tissue at autopsy.

Design, setting, and participants

This multicohort study selected data from 10 longitudinal cohort studies of normal aging and AD. Cohorts had variable recruitment criteria and follow-up intervals and included population-based and clinic-based samples. Inclusion in our analysis required APOE genotype

SUBMITTER: Hohman TJ 

PROVIDER: S-EPMC6142927 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature