Anti-Tumor Necrosis Factor Therapy and Incidence of Parkinson Disease Among Patients With Inflammatory Bowel Disease.

ABSTRACT:

Importance

Despite established genetic and pathophysiologic links between inflammatory bowel disease (IBD) and Parkinson disease (PD), clinical data supporting this association remain scarce. Although systemic inflammation is considered a potential biological mechanism shared between the 2 diseases, the role of reduced systemic inflammation through IBD-directed anti-tumor necrosis factor (anti-TNF) therapy in PD risk is largely unknown.

Objective

To compare the incidence of PD among individuals with or without IBD and to assess whether PD risk among patients with IBD is altered by anti-TNF therapy.

Design, setting, and participants

This is a retrospective cohort study analyzing information in the Truven Health MarketScan administrative claims database and the Medicare

SUBMITTER: Peter I 

PROVIDER: S-EPMC6142934 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature