Prevalence and Outcomes of Amyloid Positivity Among Persons Without Dementia in a Longitudinal, Population-Based Setting.

ABSTRACT: Importance:Brain amyloid deposition is a marker of Alzheimer disease (AD) pathology. The population-based prevalence and outcomes of amyloid positivity in a population without dementia are important for understanding the trajectory of amyloid positivity to clinically significant outcomes and for designing AD prevention trials. Objective:To determine prevalence and outcomes of amyloid positivity in a population without dementia. Design, Setting, and Participants:In the prospective, population-based Mayo Clinic Study of Aging in Olmsted County, Minnesota, participants without dementia were randomly selected from the county population and were clinically and cognitively evaluated at baseline and every 15 months from August 1, 2008, to September 18, 2018. They were also invited to undergo carb

SUBMITTER: Roberts RO 

PROVIDER: S-EPMC6142936 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature