Incidence and Risk of Second Primary Malignant Neoplasm After a First Head and Neck Squamous Cell Carcinoma.

ABSTRACT:

Importance

Second primary malignant neoplasms (SPMNs) are the leading cause of death in survivors of head and neck squamous cell carcinoma (HNSCC). Recently, human papillomavirus (HPV) has emerged as a risk factor for oropharyngeal squamous cell carcinoma and has different prognosis from classic tobacco/alcohol-associated HNSCC. This suggests that there also may be different risks and burden of SPMNs among patients who's HNSCC were from HPV or tobacco and/or alcohol.

Objective

To assess SPMN risks and burden in a large US cohort of patients with a first potentially HPV-associated HNSCC vs non-HPV-associated HNSCC.

Design, setting, and participants

In this population-based retrospective cohort study, 109 512 adult patients diagnosed with HNSCC between 2000 and 2014 wer

SUBMITTER: Adjei Boakye E 

PROVIDER: S-EPMC6142994 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature