Association of Circulating Tumor Cell Status With Benefit of Radiotherapy and Survival in Early-Stage Breast Cancer.

ABSTRACT:

Importance

Circulating tumor cells (CTCs) represent the liquid component of solid tumors and are a surrogate marker for residual cancer burden. Although CTC status is prognostic of recurrence and death in breast cancer, its role in guiding clinical management remains unknown.

Objective

To determine whether CTC status is predictive of radiotherapeutic benefit in early-stage breast cancer.

Design, setting, and participants

The cohort studies in the present analysis included patients with stages pT1 to pT2 and pN0 to pN1 breast cancer and known CTC status from the National Cancer Database (NCDB) and the multicenter phase 3 SUCCESS clinical trial. Multivariable parametric accelerated failure time models were used to evaluate the association of CTC status and radiotherapy

SUBMITTER: Goodman CR 

PROVIDER: S-EPMC6143053 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature