Sudden vs Pressure Wean From Nasal Continuous Positive Airway Pressure in Infants Born Before 32 Weeks of Gestation: A Randomized Clinical Trial.

ABSTRACT:

Importance

Nasal continuous positive airway pressure (nCPAP) is a well-established treatment of respiratory distress syndrome in preterm infants. Suboptimal weaning from nCPAP may be associated with lung injury, pulmonary morbidity, and infant weight gain. To our knowledge, the best weaning strategy from nCPAP is unknown.

Objective

To compare the effect of sudden wean and pressure wean from nCPAP in very preterm infants.

Design, setting, and participants

A randomized, clinical, open-label, multicenter trial was conducted at 6 neonatal intensive care units in Denmark from September 2012 to December 2016 and included infants born before 32 weeks of gestation.

Interventions

Sudden wean with discontinuation of nCPAP without a prior reduction in pressure. Pressure w

SUBMITTER: Jensen CF 

PROVIDER: S-EPMC6143058 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature