Association of APOL1 With Heart Failure With Preserved Ejection Fraction in Postmenopausal African American Women.

ABSTRACT:

Importance

APOL1 genotypes are associated with kidney diseases in African American individuals and may influence cardiovascular disease and mortality risk, but findings have been inconsistent.

Objective

To discern whether high-risk APOL1 genotypes are associated with cardiovascular disease and stroke in postmenopausal African American women, who are at high risk for these outcomes.

Design, setting, and participants

The Women's Health Initiative is a prospective cohort that enrolled 161 838 postmenopausal women into clinical trials and an observational study between 1993 and 1998. This study includes 11 137 African American women participants who had a clinical event from enrollment to June 2014. Data analyses were completed from January 2017 to August 2017.

Exposur

SUBMITTER: Franceschini N 

PROVIDER: S-EPMC6143074 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature