Association of Coffee Drinking With Mortality by Genetic Variation in Caffeine Metabolism: Findings From the UK Biobank.

ABSTRACT:

Importance

Prospective cohorts in North America, Europe, and Asia show consistent inverse associations between coffee drinking and mortality, including deaths from cardiovascular disease and some cancers. However, concerns about coffee, particularly among people with common genetic polymorphisms affecting caffeine metabolism and among those drinking more than 5 cups per day, remain.

Objective

To evaluate associations of coffee drinking with mortality by genetic caffeine metabolism score.

Design, setting, and participants

The UK Biobank is a population-based study that invited approximately 9.2 million individuals from across the United Kingdom to participate. We used baseline demographic, lifestyle, and genetic data form the UK Biobank cohort, with follow-up beginning

SUBMITTER: Loftfield E 

PROVIDER: S-EPMC6143111 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature