Association of Retinal Ganglion Cell Layer Thickness With Future Disease Activity in Patients With Clinically Isolated Syndrome.

ABSTRACT:

Importance

Clinically isolated syndrome (CIS) describes a first clinical incident suggestive of multiple sclerosis (MS). Identifying patients with CIS who have a high risk of future disease activity and subsequent MS diagnosis is crucial for patient monitoring and the initiation of disease-modifying therapy.

Objective

To investigate the association of retinal optical coherence tomography (OCT) results with future disease activity in patients with CIS.

Design, setting, and participants

This prospective, longitudinal cohort study took place between January 2011 and May 2017 at 2 German tertiary referral centers. A total of 179 patients with CIS were screened (80 in Berlin and 99 in Munich). Patients underwent neurological examination, magnetic resonance imaging (MRI), a

SUBMITTER: Zimmermann HG 

PROVIDER: S-EPMC6143115 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature