Novel anti-inflammatory film as a delivery system for the external medication with bioactive phytochemical "Apocynin".

ABSTRACT:

Purpose

Recently, Apocynin (APO) has emerged as a bioactive phytochemical with potent antioxidant and anti-inflammatory properties. No reports have been published so far concerning its topical application as a pharmaceutical dosage form for prospective use. To the best of our knowledge, this is the first study to fabricate novel anti-inflammatory film for external medication with APO.

Methods

APO film was prepared using casein (CAS) as a natural protein film former by solvent casting technique. The medicated film was extensively evaluated in terms of its various physicochemical characteristics, ex vivo skin permeation profile, stability, and finally in vivo anti-inflammatory activity on carrageenan-induced rat paw edema.

Results

The film represented satisfactory mecha

SUBMITTER: Anter HM 

PROVIDER: S-EPMC6143133 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature