Circulatory hepcidin is associated with the anti-inflammatory response but not with iron or anemic status in childhood malaria.

ABSTRACT: Cerebral malaria (CM) and severe malarial anemia (SMA) are the most serious life-threatening clinical syndromes of Plasmodium falciparum infection in childhood. Therefore, it is important to understand the pathology underlying the development of CM and SMA as opposed to uncomplicated malaria (UM). Increased levels of hepcidin have been associated with UM, but its level and role in severe malarial disease remains to be investigated. Plasma and clinical data were obtained as part of a prospective case-control study of severe childhood malaria at the main tertiary hospital of the city of Ibadan, Nigeria. Here, we report that hepcidin levels are lower in children with SMA or CM than in those with milder outcome (UM). While different profiles of pro- and anti-inflammatory cytokines were observe

SUBMITTER: Burte F 

PROVIDER: S-EPMC6143155 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature