An Ancestry Informative Marker Set Which Recapitulates the Known Fine Structure of Populations in South Asia.

ABSTRACT: The inference of genomic ancestry using ancestry informative markers (AIMs) can be useful for a range of studies in evolutionary genetics, biomedical research, and forensic analyses. However, the determination of AIMs for highly admixed populations with complex ancestries has remained a formidable challenge. Given the immense genetic heterogeneity and unique population structure of the Indian subcontinent, here we sought to derive AIMs that would yield a cohesive and faithful understanding of South Asian genetic origins. To discern the most optimal strategy for extracting AIMs for South Asians we compared three commonly used AIMs-determining methods namely, Infocalc, FST, and Smart Principal Component Analysis with ADMIXTURE, using previously published whole genome data from the Indian sub

SUBMITTER: Das R 

PROVIDER: S-EPMC6143162 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature