A Hypermorphic Nfkbid Allele Contributes to Impaired Thymic Deletion of Autoreactive Diabetogenic CD8⁺ T Cells in NOD Mice.

ABSTRACT: In both NOD mice and humans, the development of type 1 diabetes (T1D) is dependent in part on autoreactive CD8⁺ T cells recognizing pancreatic β cell peptides presented by often quite common MHC class I variants. Studies in NOD mice previously revealed that the common H2-K^d and/or H2-D^b class I molecules expressed by this strain aberrantly lose the ability to mediate the thymic deletion of pathogenic CD8⁺ T cell responses through interactions with T1D susceptibility genes outside the MHC. A gene(s) mapping to proximal chromosome 7 was previously shown to be an important contributor to the failure of the common class I molecules expressed by NOD mice to mediate the normal thymic negative selection of diabetogenic CD8⁺ T cells. Using an

SUBMITTER: Presa M 

PROVIDER: S-EPMC6143397 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature