Association of MicroRNA Polymorphisms With Hepatocellular Carcinoma in an Iranian Population.

ABSTRACT:

Background

Single nucleotide polymorphisms (SNPs) can modulate various biological processes by influencing microRNA (miRNA) biogenesis and altering target selection. Common SNPs may alter the processing of miRNA and may be associated with hepatocellular carcinoma (HCC). We investigated the relationship between miR-499A>G, miR-149C>T, miR-196a2T>C, and miR-146aG>C and HCC susceptibility, examining the interaction of the miRNAs with hepatitis B virus (HBV).

Methods

We evaluated the associations of miR-499A>G (rs3746444), miR-149C>T (rs2292832), miR-196a2T>C (rs11614913), and miR-146aG>C (rs2910164) with HCC susceptibility in 100 HCC patients (70 males and 30 females) and 120 healthy controls (70 males and 50 females), usi

SUBMITTER: Farokhizadeh Z 

PROVIDER: S-EPMC6143471 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature