Hemodialysis-related changes in phenotypical features of monocytes.

ABSTRACT: Hemodialysis (HD) patients exhibit chronic inflammation and leukocyte activation. We investigated the surface-marker profile of monocytes by flow cytometry to assess the chronic effect of uremia and the acute effect of dialysis on their phenotypical and functional features in 16 healthy controls (CON) and 15 HD patients before and after a polysulfone-based dialysis session. Median fluorescence intensities were analyzed indicating expression of CD14, CD16, integrins (CD11b, CD18), chemokine receptors (CCR2, CX3CR1), scavenger receptors (CD36, CD163) and Toll-like receptor-2 (TLR2). Before and after dialysis, HD patients harbour 0.9-fold less CD14⁺⁺CD16^- (Mo1), 1.8-fold more CD14⁺⁺CD16⁺ (Mo2) and CD14⁺CD16⁺⁺ (Mo3) monocytes th

SUBMITTER: Liakopoulos V 

PROVIDER: S-EPMC6143543 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature