Wide-Field Functional Microscopy of Peripheral Nerve Injury and Regeneration.

ABSTRACT: Severe peripheral nerve injuries often result in partial repair and lifelong disabilities in patients. New surgical techniques and better graft tissues are being studied to accelerate regeneration and improve functional recovery. Currently, limited tools are available to provide in vivo monitoring of changes in nerve physiology such as myelination and vascularization, and this has impeded the development of new therapeutic options. We have developed a wide-field and label-free functional microscopy platform based on angiographic and vectorial birefringence methods in optical coherence tomography (OCT). By incorporating the directionality of the birefringence, which was neglected in the previously reported polarization-sensitive OCT techniques for nerve imaging, vectorial birefringence cont

SUBMITTER: Nam AS 

PROVIDER: S-EPMC6143548 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature