Involvement of the Tetraspanin 2 (TSPAN2) Gene in Migraine: A Case-Control Study in Han Chinese.

ABSTRACT: Tetraspanin 2 (TSPAN2) belongs to the tetraspanin superfamily. Previous studies have identified significant associations of the TSPAN2 single nucleotide polymorphisms (SNPs) rs12134493 and rs2078371 with migraine in Western populations; however, these associations need to be confirmed in the Chinese Han population. In addition, we carried out further studies to see whether TSPAN2 is associated with susceptibility to migraine to provide new clinical evidence. A case-control study (425 patients with migraine and 425 healthy controls) in a Chinese Han population was performed to evaluate the associations between migraine and TSPAN2 via a genotype-phenotype analysis between TSPAN2 and clinical symptoms. The SNP rs2078371 was found to be significantly associated with

SUBMITTER: Fang J 

PROVIDER: S-EPMC6143784 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature