Circadian rest-activity rhythm as an objective biomarker of patient-reported outcomes in patients with advanced cancer.

ABSTRACT:

Background

Psychosocial symptoms often cluster together, are refractory to treatment, and impair health-related quality of life (HR-QoL) in cancer patients. The contribution of circadian rhythm alterations to systemic symptoms has been overlooked in cancer, despite a causal link shown under jet lag and shift work conditions. We investigated whether the circadian rest-activity rhythm provides a reliable and objective estimate of the most frequent patient-reported outcome measures (PROMs).

Methods

Two datasets were used, each involving concomitant 3-day time series of wrist actigraphy and HR-QoL questionnaires: EORTC QLQ-C30 was completed once by 237 patients with metastatic colorectal cancer; MD Anderson Symptom Inventory (MDASI) was completed daily by 31 patients with advanc

SUBMITTER: Innominato PF 

PROVIDER: S-EPMC6143939 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature