Cancer of unknown primary-Epidemiological trends and relevance of comprehensive genomic profiling.

ABSTRACT:

Background

Cancer of unknown primary (CUP) is a distinct clinicopathological entity with poor prognosis, frequently resistant to chemotherapy. Comprehensive genomic profiling (CGP) by next-generation sequencing potentially identifies novel treatment options for CUP patients. The objective of this study was to determine incidence and survival trends and to discuss the value of CGP in CUP patients.

Methods

Age-standardized incidence rates (ASR) per 100 000 were calculated for 2935 CUP patients from 1981 to 2014 using cancer registry data of the canton of Zurich, Switzerland. Kaplan-Meier survival curves were estimated for sex, age, and histological groups. Cox proportional hazards regression models were used to estimate adjusted hazard ratios (HR). A literature review was cond

SUBMITTER: Binder C 

PROVIDER: S-EPMC6144156 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature