Profiles of immune infiltration in colorectal cancer and their clinical significant: A gene expression-based study.

ABSTRACT: Immune infiltration of colorectal cancer (CRC) is closely associated with clinical outcome. However, previous work has not accounted for the diversity of functionally distinct cell types that make up the immune response. In this study, based on a deconvolution algorithm (known as CIBERSORT) and clinical annotated expression profiles, we comprehensively analyzed the tumor-infiltrating immune cells present in CRC for the first time. The fraction of 22 immune cells subpopulations was evaluated to determine the associations between each cell type and survival and response to chemotherapy. As a result, profiles of immune infiltration vary significantly between paired cancer and paracancerous tissue and the variation could characterize the individual differences. Of the cell subpopulations inves

SUBMITTER: Xiong Y 

PROVIDER: S-EPMC6144159 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature