Physiological and pathological high frequency oscillations in focal epilepsy.

ABSTRACT:

Objective

This study investigates high-frequency oscillations (HFOs; 65-600 Hz) as a biomarker of epileptogenic brain and explores three barriers to their clinical translation: (1) Distinguishing pathological HFOs (pathHFO) from physiological HFOs (physHFO). (2) Classifying tissue under individual electrodes as epileptogenic (3) Reproducing results across laboratories.

Methods

We recorded HFOs using intracranial EEG (iEEG) in 90 patients with focal epilepsy and 11 patients without epilepsy. In nine patients with epilepsy putative physHFOs were induced by cognitive or motor tasks. HFOs were identified using validated detectors. A support vector machine (SVM) using HFO features was developed to classify tissue under individual electrodes as normal or epileptogenic.

Results<

SUBMITTER: Cimbalnik J 

PROVIDER: S-EPMC6144446 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature