Caffeine for apnea of prematurity and brain development at 11 years of age.

ABSTRACT:

Objective

Caffeine therapy for apnea of prematurity has been reported to improve brain white matter microstructure at term-equivalent age, but its long-term effects are unknown. This study aimed to investigate whether caffeine affects (1) brain structure at 11 years of age, and (2) brain development from term-equivalent age to 11 years of age, compared with placebo.

Methods

Preterm infants born ≤1250 g were randomly allocated to caffeine or placebo. Magnetic resonance imaging (MRI) was performed on 70 participants (33 caffeine, 37 placebo) at term-equivalent age and 117 participants (63 caffeine, 54 placebo) at 11 years of age. Global and regional brain volumes and white matter microstructure were measured at both time points.

Results

In general, there was little evid

SUBMITTER: Kelly CE 

PROVIDER: S-EPMC6144456 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature