The human Obg protein GTPBP10 is involved in mitoribosomal biogenesis.

ABSTRACT: The human mitochondrial translation apparatus, which synthesizes the core subunits of the oxidative phosphorylation system, is of central interest as mutations in several genes encoding for mitoribosomal proteins or translation factors cause severe human diseases. Little is known, how this complex machinery assembles from nuclear-encoded protein components and mitochondrial-encoded RNAs, and which ancillary factors are required to form a functional mitoribosome. We have characterized the human Obg protein GTPBP10, which associates specifically with the mitoribosomal large subunit at a late maturation state. Defining its interactome, we have shown that GTPBP10 is in a complex with other mtLSU biogenesis factors including mitochondrial RNA granule components, the 16S rRNA module and late mtL

SUBMITTER: Lavdovskaia E 

PROVIDER: S-EPMC6144781 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature