Evolutionary insights into Trm112-methyltransferase holoenzymes involved in translation between archaea and eukaryotes.

ABSTRACT: Protein synthesis is a complex and highly coordinated process requiring many different protein factors as well as various types of nucleic acids. All translation machinery components require multiple maturation events to be functional. These include post-transcriptional and post-translational modification steps and methylations are the most frequent among these events. In eukaryotes, Trm112, a small protein (COG2835) conserved in all three domains of life, interacts and activates four methyltransferases (Bud23, Trm9, Trm11 and Mtq2) that target different components of the translation machinery (rRNA, tRNAs, release factors). To clarify the function of Trm112 in archaea, we have characterized functionally and structurally its interaction network using Haloferax volcanii as model system. Thi

SUBMITTER: van Tran N 

PROVIDER: S-EPMC6144793 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature