Extracellular matrix collagen I promotes the tumor progression of residual hepatocellular carcinoma after heat treatment.

ABSTRACT:

Background

Accelerated malignant behaviors induced by insufficient thermal ablation have been increasingly reported, however, the exact mechanisms are still unclear. Here, we investigated the importance of the extracellular matrix (ECM) in modulating the progression of residual hepatocellular carcinoma (HCC) after heat treatment.

Methods

Heat-exposed residual HCC cells were cultured in different ECM gels. We used basement membrane gel (Matrigel) to simulate the normal microenvironment and collagen I to model the pathological stromal ECM. The alterations of morphology and parameters of proliferation, epithelial-mesenchymal transition (EMT) and stemness were analyzed in vitro and in vivo.

Results

Increased collagen I deposition was observed at the periablational zone af

SUBMITTER: Zhang R 

PROVIDER: S-EPMC6145107 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature