Rapid dissemination of alpha-synuclein seeds through neural circuits in an in-vivo prion-like seeding experiment.

ABSTRACT: Accumulating evidence suggests that the lesions of Parkinson's disease (PD) expand due to transneuronal spreading of fibrils composed of misfolded alpha-synuclein (a-syn), over the course of 5-10 years. However, the precise mechanisms and the processes underlying the spread of these fibril seeds have not been clarified in vivo. Here, we investigated the speed of a-syn transmission, which has not been a focus of previous a-syn transmission experiments, and whether a-syn pathologies spread in a neural circuit-dependent manner in the mouse brain. We injected a-syn preformed fibrils (PFFs), which are seeds for the propagation of a-syn deposits, either before or after callosotomy, to disconnect bilateral hemispheric connections. In mice that underwent callosotomy before the injection, the propa

SUBMITTER: Okuzumi A 

PROVIDER: S-EPMC6145187 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature