The impact of transcranial magnetic stimulation on diagnostic confidence in patients with Alzheimer disease.

ABSTRACT:

Background

Cholinergic dysfunction is a key abnormality in Alzheimer disease (AD) that can be detected in vivo with transcranial magnetic stimulation (TMS) protocols. Although TMS has clearly demonstrated analytical validity, its clinical utility is still debated. In the present study, we evaluated the incremental diagnostic value, expressed in terms of diagnostic confidence of Alzheimer disease (DCAD; range 0-100), of TMS measures in addition to the routine clinical diagnostic assessment in patients evaluated for cognitive impairment as compared with validated biomarkers of amyloidosis.

Methods

One hundred twenty patients with dementia were included and scored in terms of DCAD in a three-step assessment based on (1) demographic, clinical, and neuropsychological evaluations

SUBMITTER: Benussi A 

PROVIDER: S-EPMC6145195 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature