Coordination-Responsive Longitudinal Relaxation Tuning as a Versatile MRI Sensing Protocol for Malignancy Targets.

ABSTRACT: Biomarkers (e.g., acidity, H₂O₂, hypoxia, and specific molecules) as one primary component of tumor microenvironments are closely associated with occurrence, invasion, and metastasis of malignancy, thus can act as biological targets. However, their monitoring remains a challenging task. Herein, a coordination-dependent longitudinal relaxation tuning (CLRT) that occurs between a Mn²⁺ "donor" and a Mn²⁺ "acceptor" is established to enable biological target sensing. Relying on the differences of coordination ability and spatial structure between donors and acceptors, the biological targets as Mn²⁺ acceptor can take Mn²⁺ away from the donors (i.e., modified ligands) in nanoscale probes, which consequently varies T1-weighted (T1W

SUBMITTER: Zhang K 

PROVIDER: S-EPMC6145269 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature